个人简历
姓名：刘亚平
职称：教授，博导，硕导
研究领域：药食同源植物中功效分子及其活性部位功能评价
主讲课程：高等食品化学、波谱解析、食品工厂设计与环境保护、食品化学实验
个人简介：刘亚平，教授/博导，昆明理工大学食品科学与工程学院教师。2012年毕业于中国科学院昆明植物研究所植物化学与西部植物资源可持续利用国家重点实验室，同年留在该国家重点实验室工作。于2020年11月调入昆明理工大学。至今共发表研究论文120余篇，其中SCI研究论文100余篇，包括第一作者和共通讯作者共发表研究论文56篇，其中SCI论文48篇，包括中科院JCR分区一区论文的6篇，中科院JCR分区二区的10篇；共同申请专利8项，8项获得授权，包括2项国际专利。主持国家及省部级项目10余项，包括国家自然科学基金面上项目、地区基金、青年基金、云南省重点研发计划、云南省高层次人才培养支持计划“青年拔尖人才”项目、以及云南省基础研究面上项目、云南省和昆工双一流建设面上项目。参与完成了国家自然科学基金杰出青年基金、联合基金、国家重大新药创新等项目的完成，作为主要完成人参与完后新药灯台叶总生物碱胶囊的I、II期临床研究以及成果转让。
主要研究项目：
1、主持的研究项目：
（1）国家自然科学基金地区基金“选择性抑制非小细胞肺癌的吲哚生物碱结构功能与作用机制”，2024.01-2027.12，项目编号为32360114，直接经费32万元，主持，在研。
（2）云南省基础研究专项—面上项目“芒果非食用部位中抑制氧化应激活性物质和抗衰老作用机制研究”，2022.06-2025.05，项目编号为202101AT070436，资助经费10万，主持，在研。
（3）云南省昆明理工大学“双一流”创建联合专项“基于液质联用（UPLC-DAD-HRMS/MS）技术深入挖掘新颖的吲哚生物碱及其抗肿瘤活性研究”，2021.12 - 2024.11，项目编号为202101BE070001-053，资助经费20万，主持，在研。
（4）国家自然科学基金面上项目“马钱族中抗胶质瘤干细胞的吲哚生物碱结构与活性研究”，2019.1-2022.12，项目编号为31872676，直接经费60万元，主持，在研。
（5）云南省生物医药领域科技计划项目子课题，“食用玫瑰等6种云南特色药食同源植物的物质基础研究”，2019.1-2021.12，项目编号为2019ZF010，资助经费150万，主持，在研。
2、负责的科研平台、团队及人才项目：
（1）云南省高层次人才培养支持计划青年拔尖人才“基于新药启发的吲哚生物碱新颖结构及抗肿瘤干细胞活性研究”， 2021.01-2025.12,资助经费50万，主持，在研。
（2）昆明理工大学高层次人才平台建设项目，2021.01-2028.12,资助经费80万，主持，在研。
3、承担的教学改革项目：
（1）2022年云南省专业学位案例库—《高等食品化学》案例库建设项目，2022.01-2024.12，资助经费3万元，主持，在研。
近期的代表性论文专利：
Chen, T. M.; Teng, S. F.; Yang, H. L.; Zhao, Y. L.; Zhang, J. X.; Liu, J. T.; Zhou W. B. *; Liu, Y. P. *; Cheng, G. G.* The investigation on an ethnic medicinal plant of Elsholtiza bodinieri Vaniot: chemical constituents, acute, 28-day subacute and 90-day subchronic toxicity evaluation Journal of Ethnopharmacology 2024, 335, 118635.
Li, Y. Q.; Qiu, L. Y.; Wang, Y. F.; Wang, Z. X.; Cheng, G. G.*; Liu, Y. P. *. Phytochemicals from the rhizome of Bletilla formosana and their antioxidant, cytoprotective and anti-inflammatory activities. Food Bioscience 2024, 60, 104339.
Zhang, J. X.; Zhang, J K.; Wang, X. Q.; Chen, T. M.; Wang, Z. X.; Liu, Y. P. *; Cheng, G. G.*. Isolation and structural characterization of flavonoids from E Se tea and their synergistic inhibitory effects on lipid accumulation via regulating AMPK/ACC pathway. Food Bioscience 2024, 60, 104517.
Wang, Y. C.; Zhang, J.; Zhao, T. R.; Cao, J. X.; Khan, A.; Wang, Z. X.*; Liu, Y. P. *; Cheng, G. G.* Sub-Acute, subacute, and chronic toxicity evaluation of Bletilla formosana tubers in rats. Food Safety and Health 2024, 2, 117-132.
Zhang, X. Y.; Xue, Q. W. ; Zhao, J. H. ; Zhang, H. B.; Dong, J. H.; Cao, J. X.; Wang, Y. D.; Liu, Y. P. *; Cheng, G. G.* Chemical Constituents, Hypolipidemic, and Hypoglycemic Activities of Edgeworthia gardneri Flowers. Plant Foods for Human Nutrition. 2024, 79, 440-450.
Teng, S. F.; He, J. J.; Wang, X. Q.; Li, Y. Q.; Khan, A.; Zhao, T. R.; Wang, Y. D.; Cheng, G. G.*, Liu, Y. P. * A molecular networking-based isolation of gardneria alkaloids from Gardneria distincta and their anti-inflammatory activity. Phytochemistry 2023, 209, 113639.
Zhang, J.; Chen, T. M.; Wang, Z. X.; Zhou, W. B.; Ullah, H.; Cao, J. X.; Liu, Y. P. *; Cheng, G. G.* The protective effect and mechanism of mangiferin on D-galactose-induced oxidative stress and cognitive impairment in aging mice by anintegrated network pharmacology and experimental validation strategy Food Frontiers, 2023, 4, 1543-2096.
Teng, S. F.; Li, F. R.; Cui, Q. M.; Khan, A.; He, T.;, Luo, X. D.*; Liu, Y. P. *; Cheng, G. G.* A review on the genus Melodinus: traditional uses, phytochemical diversity and pharmacological activities of indole alkaloids Phytochemistry Review 2023, https://doi.org/10.1007/s11101-023-09871-2.
Zhang, X. Y.; Li, M. C.; Zhen, L.; Wang, Y. D.; Wang, Y. F.; Qin, Y. Y.; Zhang, Z.H.; Zhao, T. R.; Cao, J. X.; Liu, Y. P. *; Cheng, G. G.* Ultra-High Hydrostatic Pressure Pretreatment on White Que Zui Tea: Chemical Constituents, Antioxidant, Cytoprotective, and Anti-Inflammatory Activities Foods 2023, 12, 628.
Zhao, J.-H.; Li, J.; Zhang, X.-Y.; Shi, S.; Wang, L.; Yuan, M.-L.; Liu, Y. P. *; Wang, Y.-D.* Confusoside from Anneslea fragrans Alleviates Acetaminophen-Induced Liver Injury in HepG2 via PI3K-CASP3 Signaling Pathway Molecules 2023, 28, 1932.
Yang, M.L.; Can Lu, C.; Fan, Z. F.; Zhao, T. R.; Cheng, G. G.; Wang, Y.-D.*, Cao, J. X. *; Liu, Y. P. * Hypoglycemic and hypolipidemic effects of Epigynum auritum in high fat diet and streptozotocin-induced diabetic rats Journal of ethnopharmacology, 2022, 288, 114986.
Cheng C. S.; Gui, Q.-H.; Zhang, J.-K.; Tao, J.-H.; Zhao, T.-R.; Cao, J.-X.; Cheng, G.-G.; Lai, G.-F*.; Liu, Y. P. * Phenolic Constituents, Phenolic Constituents, Antioxidant and Cytoprotective Activities, Enzyme Inhibition Abilities of Five Fractions from Vaccinium dunalianum Wight. Molecules 2022, 27, 3432.
Cui Q. M.; Cui X. Y.; Teng S. F.; He S. Y.; Liu, Y. P. *; Cheng, G. G.* Chemical constituents from Melodinus axillaris W. T. Wang and their chemotaxonomic significance. Biochemical Systematics and Ecology. 2022, 105, 104530.
Zhu, P. F. #; Cheng, G.G. #; Zhao, L.Q.; Khan, A.; Yang, X.W.; Zhang, B.-Y.; Li, M.C.; Liu, Y. P. *; Luo, X.-D. *. Antioxidant and Cytoprotective Effects of New Diarylheptanoids from Rhynchanthus beesianus Journal of Agriculture and Food Chemistry 2021, 69, 6229-6239.
Yuan, H. L.; # Zhao, Y. L.#, Qin, X. J., Liu, Y. P. *, Yang, X. W. *; Luo, X. D*. Diverse isoquinolines with anti-inflammatory and analgesic bioactivities from Hypecoum erectum Journal of ethnopharmacology 2021, 270, 113811.
Cheng, G.-G.#; Liu, Y.-P. #; Gu, J.; Qian, S.-Y.; Yang, H.-J.; Na, Z.-Y.; Luo, X.-D., Phytochemicals and Allelopathy of Induced Water Hyacinth against Microcystis aeruginosa Journal of Natural Products 2021. 84, 1772-1779.
Li, F. R.; Wang, Y. D.; He, S. Y.; K. A.; Xue, Q. W.; Cui, Q. M.; Liu. L.; Liu, Y. P.*; Cheng, G. G.* Targeted isolation of terpenoid indole alkaloids from Melodinus cochinchinensis (Lour.) Merr. using molecular networking and their biological activities Industrial Crops and Products 2020, 157 112922.
Zhu, P. F.; Zhao, Y. L.; Dai, Z.; Qin, X.J.; Yuan, H. L.; Jin Q.; Wang, Y. F.; Liu, Y. P.* Phenolic Amides with Immunomodulatory Activity from the Nonpolysaccharide Fraction of Lycium barbarum Fruits Journal of Agricultural Food Chemistry 2020, 68, 3079−3087.
Yuan, H. L. #; Zhao, Y. L.; # Ding, C. F.; Zhu, P. F.; Jin, Q.; Liu, Y. P. *; Ding, Z. T.; Luo, X. D*. Anti-inflammatory and antinociceptive effects of Curcuma kwangsiensis and its bioactive terpenoids in vivo and in vitro. Journal of Ethnopharmacology. 2020, 259, 112935,
Xie, T. Z.; Zhao, Y. L., He, J. J.; Zhao, L. X.; Wei, X.; Liu, Y. P. *; Luo, X. D*. Monoterpenoid indole alkaloids from the stems of Kopsia officinalis. Fitoterapia 2020, 143, 104547.
招生专业：食品科学、生物与医药、农产品加工及贮藏
电子邮箱：liuyaping@kust.edu.cn
